Abstract

Analgesic, anti-inflammatory, and antipyretic effects are all present in the NSAID ibuprofen. Ibuprofen prescriptions are frequently given in clinical settings. The initial work reporting is here. For the purpose of determining ibuprofen, a high-performance liquid chromatography method was created and approved. Ibuprofen-containing compounds may be subject to quality control using this technique. By carefully tuning chromatographic parameters such flow rate, column, detection wavelength, column temperature, buffer solution, and gradient elution, this method was effectively developed. The separation effectiveness and robustness of an Agilent Optima-17ms (250 x 4.6mm, 0.5 m particle size) column were taken into consideration. For detection, a photodiode-array detector was employed. In accordance with the recommendations of the International Conference on Harmonization (ICH), this method was validated to establish its superiority and stability.

References

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